Using today’s mammogram to find tomorrow’s heart disease

iCAD and Solis Mammography Ink Deal to Collaborate on Use of AI to Evaluate Risk of Cardiovascular Disease

Multi-year strategic research and commercial collaboration agreement aims to significantly impact preventative care and underscores Company’s commitment to women’s health.

NASHUA, N.H. – October 11, 2022 - iCAD, Inc. (NASDAQ: ICAD), a global medical technology leader providing innovative cancer detection and therapy solutions, today announced a new development and commercial collaboration agreement with Solis Mammography, the largest independent provider of breast screening and diagnostic services in the U.S. This collaboration will focus on using mammography to define cardiovascular risk, a new application that could identify millions of women at risk for heart disease using data obtained from their mammogram. As such, this project will result in a powerful AI solution that will quantify the presence of breast arterial calcifications in a mammogram to assess the risk of cardiovascular disease (CVD).

“With heart disease being the number one killer among women in the U.S., this collaboration marks the initiation of a historical milestone for iCAD that will not only offer the potential to address a significant unmet need in patient care but also to penetrate a sizeable new market,” said Stacey Stevens, President and CEO of iCAD, Inc. “iCAD and Solis Mammography are aligned in our mutual goal to improve women’s health, and this initiative will further expand our purpose and mission, extending our ability to positively impact women’s lives into other areas outside of cancer detection and treatment.”

The new agreement will build upon the ability of iCAD’s flagship artificial intelligence (AI) solution for breast imaging, ProFound AI®, to both detect and quantify calcifications within the arteries of the breast. Moreover, the model will seek to provide radiologists with an evidence-based risk product that could help shape the trajectory of their patients’ lives and improve their cardiovascular health. ProFound AI is a high-performing breast cancer-detection and workflow solution that is already in the marketplace and implemented throughout a growing number of leading imaging facilities worldwide, including Solis Mammography centers. Trained on one of the largest available datasets, ProFound AI was the first breast AI technology for digital breast tomosynthesis (DBT), or 3D mammography, to be FDA cleared.

Breast arterial calcifications (BACs) are frequently observed on screening mammography images and were traditionally overlooked as an incidental benign finding. Emerging research suggests, however, that the amount of calcium in the arteries of the breast may correlate with an increased risk of CVD. One recent study suggests women with BACs are 23 percent more likely to develop CVD, and are at a 51 percent higher risk for heart disease and stroke than women whose mammograms did not show BACs.

“Our goal at Solis Mammography is to advance the health of women through early detection. Heart disease is often underdiagnosed in women and appropriate interventions are not initiated when they can be most effective. Given that approximately 40 million women are screened each year with mammography in the U.S. alone, the evaluation of BAC offers a simple, but accurate method to identify women at high risk of CVD,” said Chirag Parghi, MD, Chief Medical Officer at Solis Mammography. “We look forward to working closely with iCAD to develop a solution that can unlock additional applications of the AI model in traditional mammography to learn about risk factors that were previously ignored. As a leader in breast imaging, it is our obligation to offer every possible bit of information from the mammogram to our patients to help them advance their health. We are pleased to partner with iCAD to help use today’s mammogram to find tomorrow’s heart disease.”

This partnership expands the companies’ relationship, as Solis Mammography adopted iCAD’s Breast AI Suite across its entire network in 2020. With more than 100 locations in the U.S. and over one million women served each year, Solis Mammography will provide clinical support for the BAC risk model. The company will also assist in developing appropriate pathways for patients in order to maximize the clinical value of the technology and accelerate adoption.

“When it comes to addressing this critical need, we know that the best path forward is partnering with leading clinical providers, as they understand the clinical pathways to apply it in daily practice and the steps necessary to drive adoption in the market,” Stevens added. “iCAD and Solis Mammography have worked closely together over the last two years in the fight against breast cancer through the application of our Breast AI Suite, and we look forward to working with their exceptional team to expand on our shared mission and take on one of the greatest threats to women’s health.”